THERES A STEP BY STEP INSTALATION MANUAL WITH PICTURES IN PDF FORMAT 
IN THE MANUAL SUBFOLDER. LOOK FOR MANUAL.PDF

!!!REAd IT!!!

anyway, heres the plain txt version

1) Unzip TOM225X.ZIP into a temporary location, your desktop for example
2) Move the AN225 folder from your temporary folder (desktop) into your
   FSX simobjects/aircrafts folder.
3) Copy the six .fx files from your temporary locations effects folder
   into your FSX/effects folder.
4) Copy your default Boeing747-400.cab file from your default Boeing747-400
   panel folder into your FSX gauges folder.